Use of PMK Glycidate in Laboratory Studies

January 7, 2020 0 By Jeff

This waxy solid is classified as a precursor and may be used for scientific purposes. The formal name of the chemical is 3-(1,3-benzodioxol-5-yl)-2-methyl-2-oxiranecarboxylic acid, methyl ester (Cas 13605-48-6). In laboratory research, it allows synthesizing other chemicals ― specifically, amphetamines and methylenedioxy phenethylamines. The output falls within the MDMA group (e.g., 3,4-MDMA). Unlike PMK, which is illegal in most states, the alternative may often be purchased freely for medical studies only.

Structure of PMK Glycidate

The molecular formula of the chemical is C12H12O5. It is a crystalline solid with λmax 242, 288 nm, and the formula weight is 236.2. Reliable sources supply genuine PMK Glycidate with purity just under 100%. 

General Reaction 

In order to obtain MDMA, the following steps must be followed within the classic approach. However, other methods do exist. Basically, it is necessary to perform oxidizing of 1-allyl-3,4-methylenedioxybenzene, which is found in plant oil safrole (or the precursor in question). A ketone is thus produced, and it later goes through condensation. For this purpose, methylamine is used. In the end, the chemical is reduced to MDMA. 

One alternative method is to first oxidize the precursor to alcohol and proceed to further oxidization to a ketone.

  • Production of PMK

This initial stage is very important, and cannot be avoided. For the goal of synthesizing a ketone known as piperonyl methyl ketone, perform either reaction: 

  • Wacker (catalytic oxidizing) or 
  • Peroxyacid (safrole-based oxidizing).

Both result in classic type (referred to as the Markovnikov product). Addition occurs on the alkene, on its most substituted end. When PMK glycidate is engaged, it is turned into PMK via treatment with hydrochloric acid.  

The required safrole usually comes from certain oils. It is important to note that sales of this product and derivatives, however, have been outlawed in the United States. This explains why the newly introduced precursor is such an important ingredient for laboratory and medical research. 

  • Imine formation 

This is a spontaneous process that is launched once the resulting ketone is put into a solution with a suitable freebase of methylamine nature. Hydrochloride salt must never be applied. In the end, it is obligatory to reduce the resulting mixture to the required end product.

  • Reduction to MDMA

This step is mandatory in order to complete permanent conversion to MDMA. It requires the presence of additional elements ― electrical cells, hydrides, aluminum-mercury amalgams, or catalytic hydrogenation. 

The end product comprises laevorotatory and dextrorotatory elements or two isomers. This means that it is usually a mix of the powerful and the weak isomer found in 50/50 proportions. The former releases large amounts of neurotransmitters ― serotonin, dopamine, and norepinephrine, while the latter boosts the first type of neurotransmitters exclusively. 

Essential Caveats

It is vital to remember that chemicals covered in the article are in no way designed for animal or human consumption. Their use is restricted to controlled laboratory environments, and the output should also be treated as a potentially dangerous substance.