Properties and Medical Use of 4-BR-PVPApril 19, 2019
4-BR-PVP is a relatively new substance that is generally used as an alternative to Alpha-PVP that has been used since 2013. It, therefore, shares many of its characteristics in terms of effects. The stimulant, which belongs to the classes of pyrovalerones and cathinones, is categorized as a norepinephrine-dopamine reuptake inhibitor.
4-BR-PVP is primarily consumed orally, with 5-10 mg classified as light dosage, 10-15 mg as common and higher dosage up to 25 mg as strong. In the case of intranasal intake, doses start with 1-5 mg (light), while the strongest possible amount is between 10 mg and 15 mg. In both cases, effects are observed for 2-5 hours.
In terms of detection, the substance may be found in body fluids (blood, urine, and plasma) by means of liquid chromatography-mass spectrometry. This is usually used in order to verify poisoning diagnosis in hospitalized patients. It may also serve as evidence in medicolegal death investigations.
Generally, the most powerful effects of the substance concern boosting the physical activity of the subjects and inciting a euphoric state. Intake causes a flood of dopamine in the human brain, which explains the subject’s condition. A neurotransmitter helping to regulate the reward and pleasure centers in the brain, dopamine is no longer reuptaken by its cells. This produces the euphoria commonly observed in research subjects.
Frequently witnessed effects of the intake include the following, aside from euphoria:
- increased palpitations;
- increased blood pressure;
The so-called comedown period (when the substance leaves the human body) is characterized by depression and fatigue, which may cause the subject to seek redosage. This is especially dangerous, as it may cause severe abuse and, in the most extreme cases, fatalities.
Symptoms of overdose include:
- muscle breakdown and, eventually,
- kidney damage.
Like any similar substance, 4-BR-PVP has addiction potential, and abuse must be avoided at all costs. Any intake of the chemical must be observed by medical professionals who should determine and later adjust suitable doses in each individual case based on the effects witnessed.
There is a lack of scientific research into the effects brought about by the long-term use of the synthetic substance. What has been demonstrated, however, is that prolonged overdose causes damage to kidneys and precipitates renal failure.
The research chemical is in no way intended for human or animal intake, and it should only be used for medical purposes. Until further studies have been completed, 4-BR-PVP must be treated with extreme caution. Uncontrollable consumption in especially high doses has been shown to cause temporary psychosis.
A number of fatalities have been reported, which were either linked to recreational abuse or combinations with other substances (the latter have caused suicidal tendencies in one case and advanced atherosclerotic coronary disease in another). Generally, the possible detrimental effects include hyperstimulation, paranoia, and hallucinations. Human consumption outside of the lab environment must be avoided at all costs.